The Effectiveness of high-intensity laser therapy on pain in tendinopathy

Tjaša Berčič 

Alma Mater Europaea University 

https://orcid.org/0009-0003-7384-0975

Mit Bracic 

Alma Mater Europaea University 

https://orcid.org/0009-0008-5493-9132

https://doi.org/10.33700/jhrs.3.2.119

Abstract

Introduction: High-intensity laser therapies (HILT) have gained significant attention in therapeutic pain treat-ment. The aim of this systematic review was to determine the effectiveness of HILT therapies in the management of different types of tendinopathy-related pain, and the long-term benefits associated with treatment process.

Methodology: A systematic literature review of prospective randomized controlled trials from electronic data-bases: Google Scholar, Pub Med, Embase, Science Direct, and ProQuest, using relevant key words, was per-formed. Randomized trials that included HILT, patients with tendinopathy, pain management, and at least one single clinically pertinent attribute were selected. Standard PRISMA protocols were followed when completing the assessment.

Results: The physical, demographic, and theoretical insights from various studies suggest that HILT is a highly promising approach for managing pain in patients with tendinopathy. The most common body parts for treating tendinopathy using this method were the shoulder, elbow, ankle, and knee. Various attributes and parameters, such as Hand function evaluated by Quick Disabilities of Arm, Shoulder and Hand Questionnaire (QDASH) and Hand-grip Strength; pain assessed by the visual analogue score (VAS) during rest or activity, 36-item short-form health survey (SF-36) for physical and mental health, and the shoulder pain and Disability Index (SPADI) for shoulder and elbow assessment, were frequently significant across studies.

Conclusion: HILT could be recommended as a treatment of choice for reducing pain and improving function in patients with tendinopathy, with potential benefits when combined with other physical therapy treatments. Further studies are needed to clarify optimal treatment protocols and long- term outcomes.

Keywords: Tendinopathy, high-intensity laser therapy (HILT),, Laser therapy, tendon, pain

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JHRS newest issue 2, Voulme 3 for 2024 has already been published

Dear colleagues and readers,

I would like to inform you that 2nd issue of the 3rd volume of Journal of Health and Rehabilitation Sciences is published online yesterday (January 29th, 2025). A total number of 7 papers are published. Next Issue 1, Vol. 4 of JHRS for the 2025 is expected to be published until June 30th, 2025.

Accessing JHRS Online

To view a current articles which appears online, please visit this LINK.

You, your colleagues, and students will be able to view articles (Full-Text PDF and XML) and have unlimited access to the journal (JHRS is an open access, international, peer reviewed and non for profit journal).

Citing Articles Using the Digital Object Identifier (DOI)

When citing articles from JHRS, we encourage you to use article’s DOI in addition to traditional citation information. This is an industry standard, a link-resolving system that allows any link to remain “persistent” even if the location of the article changes at some point in the future. Hence, when you are quoting the link for an article, you should always quote the DOI rather than the URL of our home page.

Useful Online Features for Authors

Your registration in online submission (https://jhrs.almamater.si/index.php/jhrs/user/register) will enable you with continuous information connected with JHRS. We encourage you to share publications from JHRS platform and online registration with your colleagues. You can feel free to share every publication on social media.

We invite you to the content of the JHRS and we think that you will consider publishing with Journal of Health and Rehabilitation Sciences.

Call for papers for Vol.4, Issue 1 is open until February 28th.

Suggested topics include:

• Rehabilitation Research,
• Health Research,
• Special Education Research,
• Neuropsychological Research,
• Autism Spectrum Disorders,
• Disability Research,
• Medical Aspects of Disability,
• Social Aspects of Disability,
• Master theses and PhD theses in the field,
• Book Reviews in the field.

If you have any questions or you face problems with paper submission, please feel free to contact us: editorjhrs@almamater.si

Cheers,

JHRS Editor-in-chief

Happy New Year 2025

 

JHRS has been indexed in new databases

 Dear readers,

In last months JHRS has been indexed in several databases such as:

• Open Access Journals Impact Factor
• Zeitshriften Datenbank
• Max Perutz Library, Vienna
• Kommunikations-, Informations- und Medienzentrum Hohenheim (KIM)
• Kassel University Library

Cheers,

JHRS Editor-in-chief

Press release for Slovenian media

Respected journalists,

Journal of Health and Rehabilitation Sciences (JHRS) is a multidisciplinary, peer reviewed, scholarly, international, electronic journal edited by the Alma Mater Europaea University - ECM from Slovenia and Macedonian Scientific Society for Autism from Macedonia.

This journal will fill the gap, inspire scientists to exchange knowledge and experience and contribute to the development of science and the profession, due to the increase in scientific connection. With this we will increase the awareness about health care, rehabilitation processes especially for people with disabilities. Our interest is to create a journal at the highest scientific level, which is why we look forward to the cooperation of research and academic institutions in these areas. The aim of the journal is to share and disseminate knowledge between all disciplines that work in the field of developmental diversities. All articles will be critically reviewed by at least two unknown reviewers within 2 months. JHRS allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. We are using diamond open access model.

The subject matter is broad and includes, but is not restricted to, findings from health, psychological, biological, educational, genetic, medical, psychiatric, and sociological studies, ethical, philosophical, and legal contributions that increase knowledge on the prevention and treatment of disability, and/or inform public policy and practice.

The following articles will be considered for publication: original and review articles, short report, letters to the editor, clinical experiences, survey of cases, doctoral dissertations, master of arts, editorials, rapid communications book reviews.

Authors retain copyright of the published papers and grant to the publisher the non-exclusive right to publish the article, to be cited as its original publisher in case of reuse, and to distribute it in all forms and media. Articles will be distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Authors can enter the separate, additional contractual arrangements for non-exclusive distribution of the published paper (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

Why to Publish in JHRS?

• Editorial board has great experience in publishing;
• Rapid publication;
• Rapid availability of your document world-wide;
• Studies show, that Open-Access papers are cited more than printed articles;
• Fast and professional peer review. JHRS is run by a team of experienced editors who have previously worked in publishing. The professional editors work closely with academic editors and peer reviewers to provide authors with an efficient, fair, and constructive review process;
• Quick review: The review decision will be made within two months from the date of submission.
• Indexing of your document which can be easily found in library catalogs, OAI archives and search engines on the net.
• Not for profit journal;
• Liberality in terms of language: The journal will not reject a paper merely based on the language. The authors will be guided to improve the manuscript in such case.
• We have no page charges or submission fees, and you have free use of color figures.
• Our mission is to advance excellence in the social sciences and humanities, and our status as a scholarly publisher allows us to focus on making that a reality. We re-invest all surplus back into the global scientific community, providing ongoing support for authors, researchers, and educators in every field of health and rehabilitation sciences, psychology, and related disciplines.

This August, Journal of Health and Rehabilitation Sciences celebrates two years of its existence. We spent two productive years fulfilled with a lot of challenges. We published 26 articles in 4 issues, with more than 46.200 page visits. JHRS is indexed in 42 databases, which is a great number. Editorial board is consisting with members from 21 world countries.

If you want to see the short presentation about our achievements, please visit this LINK.

The video about our activities you can find on JHRS YouTube channel.

Authors from Slovenia are kindly invited to submit an article in our JHRS. The style of referencing is from APA. The deadline for sending the manuscripts is September 30th, 2024.

With respect,

JHRS Editor-in-chief

JHRS two years with you

Dear authors, reviewers, readers,

Today, August 1st, Journal of Health and Rehabilitation Sciences celebrates two years of its existence. We spent two productive years fulfilled with lot of chanllenges. We published 26 articles in 4 issues, with around 45.000 page visits. JHRS is indexed in 41 databases which is a great number. JHRS is in the evaluation  procedure in Scopus, we hope for inclusion. Editorial board is consist with members from 21 world countries.

If you want to see the short presentation about our achievments, please visit this LINK.

The video about our activities you can find on JHRS YouTube channel. Please watch it here:

I thank everyone who made a greater or lesser contribution to the development of the journal.

Cheers,

JHRS Editor-in-chief 

Review of "Physiological psychology" by Vladimir E. Trajkovski

Andrea Ivanovska 

Macedonian Scientific Society for Autism

https://orcid.org/0009-0008-2653-2503
https://doi.org/10.33700/jhrs.2.3.98

ABSTRACT

“Physiological psychology” authored by Prof. Dr. Vladimir E. Trajkovski, represents a pivotal contribution to the field of physiological psychology. The Publisher is Faculty of Philosophy in Skopje and it was published on September 29th in Skopje. This is first edition of the book, which is printed in B5 format with ISBN 978-608-238-235-7.

This textbook, the first in the Macedonian language, elaborately explores the biological bases of behaviour. The book's scope extends beyond mere academic interest, serving as a valuable resource for students and professionals.

This book is a valuable resource for anyone fascinated by the intersection of psychology and physiology, demystifying how our biological mechanisms shape behaviour. It's a great educational resource, particularly for students and professionals in psychology, neuroscience, and similar fields, because of its exhaustive exploration of physiological psychology. From the workings of the sensory systems and the dynamism of motor functions to the neurological and cognitive complexities, the book clarifies human behaviour's roots. This book is a great candidate for readers seeking to enhance their knowledge of physiological psychology.

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Split protocol for next successful pregnancy after spontaneous abortions and pregnancy loss in Genetic Counselling Unit Split

Vida Culic 

Paediatrician medical geneticist, prof. prim, Paediatris Clinic UH, Gynecology and Obstetrics Private Outpatient Clinic

https://orcid.org/0000-0003-1352-4914

https://doi.org/10.33700/jhrs.2.3.95

ABSTRACT

Aim: Spontaneous abortion, early neonatal death and stillbirth are tragic events for the whole family. Sporadic abortion in the general population occurs at 12-15%, before the 12th weeks. The percentage increases with the age of the mother, up to 23%. Successful next pregnancy is the goal.

Methods: In a retrospective analysis from 1985 to 2010, 451 couples with one or more SAs before the 16th week of pregnancy were examined at the Genetic Counselling Unit, Pediatrics Clinics, UH Split.

Results: The highest number of SAs was recorded in the period 8-10th weeks of gestation. Furthermore, 69% of women and 66% of men had a positive family history (especially in a second-generation relative) for SA or sterility. Adverse habits (smoking, alcohol consumption) and exposure to pollutants and / or teratogens (chemicals, exposure to excessive heat or cold) did not affect the incidence of SA. Examination of serological signs (IgM + and EA +) in the presence of reactivation of infection with viruses most commonly revealed reactivation to viruses of the genus herpes viride such as HSV1, CMV and EBV, more often in women. Sideropenia or anemia with very low ferritin values ​​were found in 40% of tested women.

Conclusion: The theory of “two hits” (multifactorial inheritance) is still in the basis of SA. Under these circumstances, it is possible to achieve a normal pregnancy as needed with prenatal or preimplantation diagnostics. If there is a need for assisted fertilisation, the same procedure should be followed.

Keywords: spontaneous abortions (SA), pregnancy loss (RPL), etiology, genetic counselling

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Drug discovery and development and precision medicine for Autism Spectrum Disorder – current state

Irena Stojanovska 

Macedonian Scientific Society for Autism, Skopje, Macedonia 

https://orcid.org/0000-0001-6483-4723

https://doi.org/10.33700/jhrs.3.1.109

ABSTRACT

Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder/condition. Medical interven-tions for this condition are mainly pharmacological, and generally not tailored to precisely address the specific underlying issues in each ASD individual. Despite the extensive efforts to develop new or repurpose existing drugs over the decades, the range of medications that address this condition remains very limited.

Findings: Progress in drug development has been hindered by research design limitations and the complex, het-erogeneous nature of the ASD itself. Therefore, this article first discusses preclinical and clinical studies aimed at finding effective treatments, highlighting their shortcomings and potential solutions. It then delves into the com-plexity of ASD and the implications for drug development, such as its phenotypic and genetic heterogeneity and multifactorial etiology, and unclear diagnostic boundaries with other developmental disorders.

Exploiting the advantages of new technologies, current autism treatment research is steering towards prioritizing genetic and molecular data over phenotypic data, emphasizing the need for biologically meaningful and quantifi-able biomarkers to identify biologically defined and clinically actionable subgroups within ASD, amenable to specific treatments.

The critical role of precision medicine is underscored as a comprehensive, fundamental approach to biology-based drug development and personalized treatments. Achieving this goal requires an integrated analysis of multilayered data, utilizing multi-omics, systems biology, and machine learning approaches.

Conclusion: Lastly, the article provides a brief overview of current initiatives and private sector efforts focusing on precision medicine treatments for neurodevelopmental disorders, highlighting their progress in developing drugs through this innovative approach.

Keywords: autism, drug development, biomarkers, multi-omics, precision medicine

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Association between Autism Spectrum Disorder and Cancer - a Review from the Literature

Vladimir Trajkovski 

Institute of Special Education and Rehabilitation, Faculty of Philosophy, University “Ss. Cyril and Methodius, Skopje, Macedonia

https://orcid.org/0000-0002-8369-9501

https://doi.org/10.33700/jhrs.3.1.103

ABSTRACT

Introduction: Autism spectrum disorder (ASD) is neurodevelopmental polygenic disorder with strong genetic component. In adult period, it is associated with many chronic diseases including diabetes, hypertension, cardiovascular disease, and cancer.

The aim of this article is to show possible connection between autism spectrum disorder and some kinds of cancers, and to show possible pathways for prevention and treatment.

Methodology: The PubMed and Google Scholar databases were searched using the keywords: autism spectrum disorder, genetics, cancer, prevention and treatment.

Results: Autism spectrum disorder is associated with high rates of genomic aberrations, including chromosomal rearrangements and de novo copy-number variations. Autism and cancer share 43 risk genes, suggesting that common mechanisms underlying the functions of some of these genes could conceivably be leveraged to develop therapies not just for cancer but for autism as well. Pleiotropy, whereby gene variants exert effects on multiple phenotypes, has been the source of increasing research attention with ASD and cancer.

Germline loss-of-function PTEN mutations increase the rate of benign and malignant tumors and also manifest as ASD and macrocephaly. Mutations in TSC1 and TSC2 genes cause tuberous sclerosis complex which is characterized by cortical tubers, and neurocognitive phenotypes including epilepsy, ASD, and intellectual disability (ID).

Conclusion: There is may be an association between autism and specific forms of cancer. Further epidemiologic research in large populations is needed to elucidate the association between autism and cancer and identify explanatory factors. Approved drugs targeting oncogenic pathways might also have therapeutic value for treating autism spectrum disorder.

Keywords: autism spectrum disorder, cancer, genetics, prevention, treatment

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